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pharmaceutical manufacturing industry


Project background


The pharmaceutical manufacturing industry refers to the process that raw materials become new pharmaceutical products after physical or chemical changes. It includes the manufacturing of traditional Chinese medicine and Western medicine, veterinary medicine, and health materials. The pharmaceutical industry is a complex chemical industry, with complicated processes. Flammable substances are often produced. These flammable substances refer to the explosive gases formed after mixing with air, which may be flammable gases, flammable liquids, flammable vapors, etc. In the pharmaceutical production process, the main dangerous gases are ammonia, chlorine, formaldehyde, sulfur dioxide, hydrogen sulfide, oxygen, VOCs, ozone, solvent, etc.


Dangerous gas


Methanol (CH3OH), ethanol (C2H6O), total volatile organic compounds (TVOC), and other gases may exist in the workshops, laboratories, and warehouses of large pharmaceutical factories. Methanol has low toxicity to the human body and an anesthetic effect on the central nervous system; It has a special selective effect on the optic nerve and retina, causing pathological changes; It can cause metabolic acidosis. Alcohol is low toxicity, volatile, and central nervous system inhibitor. Long-term exposure to the high concentration of this product can irritate the nose, eyes, and mucous membrane, as well as headache, dizziness, fatigue, irritability, tremor, and nausea. Long-term skin contact can cause dryness, desquamation, chaps, and dermatitis. TVOC can cause the imbalance of immune level, affect the function of the central nervous system, dizziness, headache, drowsiness, weakness, chest tightness, and other conscious symptoms; May also affect the digestive system, loss of appetite, nausea, serious damage to the liver and hematopoietic system, allergic reactions.


According to the national standard: occupational exposure limits of hazardous factors in the workplace, methanol: PC-TWA: 25mg / m3 (17.5ppm), pc-STEL: 50mg / m3 (35ppm); Ethanol: PC-TWA, 1900mg / m3 (911ppm), pc-STEL, 2400mg / m3 (1151ppm); TVOC: PC-TWA 0.60mg/m3, pc-STEL No; PC-TWA: the average allowable exposure concentration of 8h working day and 40H working week with time as weight.

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